mSphere of Influence: the Complexity of Interferon Gamma-Mediated Pathogen Control.

Bryson, Bryan D

Bryson, Bryan D.

Affiliation

Bryson BD; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA bryand@mit.edu.

mSphere ; 6(1)2021 01 06.

Article in En | MEDLINE | ID: mdl-33408238

ABSTRACT

ABSTRACT

Bryan D. Bryson works in the field of biological engineering with a specific interest in host-mycobacterium interactions. In this mSphere of Influence article, he reflects on how "IRG1 and inducible nitric oxide synthase act redundantly with other interferon-gamma-induced factors to restrict intracellular replication of Legionella pneumophila" by Price and colleagues (J. V. Price, D. Russo, D. X. Ji, R. A. Chavez, et al., mBio 10e02629-19, 2019, https//doi.org/10.1128/mBio.02629-19) made an impact on him by reinforcing the complexity of intracellular pathogen control.

Subject(s)

Host-Pathogen Interactions; Immunity, Innate/genetics; Interferon-gamma/immunology; Legionella pneumophila/immunology; Host-Pathogen Interactions/genetics; Host-Pathogen Interactions/immunology; Humans; Legionella pneumophila/pathogenicity; Narration; Nitric Oxide Synthase Type II; Phagosomes/immunology; Phagosomes/microbiology; Protein Transport

Key words

Legionella pneumophila; interferon gamma; macrophage

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon-gamma / Legionella pneumophila / Host-Pathogen Interactions / Immunity, Innate Type of study: Qualitative_research Limits: Humans Language: En Journal: MSphere Year: 2021 Document type: Article Affiliation country: United States

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