Detrimental effects induced by diisononyl phthalate on development and behavior of Drosophila larva and potential mechanisms.
Comp Biochem Physiol C Toxicol Pharmacol
; 243: 108967, 2021 May.
Article
in En
| MEDLINE
| ID: mdl-33412299
Diisononyl phthalate (DINP) as one of the most commonly used phthalates, has been found in various environmental samples and is considered to have potential risks to ecosystem. Till now, DINP has no clear effect consensus on insects from development to behavior and even mechanisms. Here, Drosophila melanogaster was selected as model organisms and the toxic effects of DINP (0.1%, 0.2%, 0.5% and 1.0%) (v/v) on its metamorphosis, crawling behavior, intestinal cells and cellular redox balance were investigated. During metamorphosis process, lower hatching rate, longer development time, lighter body weight and malformation were observed at high concentration groups. The crawling ability of larvae was severely inhibited by DINP and the movement distance was drastically reduced. DINP could cause severe damage to the larval intestinal cells in the dose-dependent and time-dependent manners. DINP was found to induce redox imbalance with activities of two important antioxidant enzymes (catalase (CAT) and superoxide dismutase (SOD)) increasing, and reactive oxygen species (ROS) level fluctuation in larvae. Our findings provide theoretical basis and data support for scientific management of DINP to reduce ecological risk.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phthalic Acids
/
Plasticizers
/
Drosophila melanogaster
/
Larva
/
Metamorphosis, Biological
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Comp Biochem Physiol C Toxicol Pharmacol
Journal subject:
FARMACOLOGIA
/
TOXICOLOGIA
Year:
2021
Document type:
Article
Affiliation country:
China
Country of publication:
United States