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The endocannabinoid 2-arachidonoylglycerol and dual ABHD6/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity.
Kokona, Despina; Spyridakos, Dimitris; Tzatzarakis, Manolis; Papadogkonaki, Sofia; Filidou, Eirini; Arvanitidis, Konstantinos I; Kolios, George; Lamani, Manjunath; Makriyannis, Alexandros; Malamas, Michael S; Thermos, Kyriaki.
Affiliation
  • Kokona D; Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Crete, 71003, Greece. Electronic address: Despina.Kokona@insel.ch.
  • Spyridakos D; Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Crete, 71003, Greece. Electronic address: med2p1080145@med.uoc.gr.
  • Tzatzarakis M; Department of Toxicology, School of Medicine, University of Crete, Heraklion, Crete, 71003, Greece. Electronic address: tzatzarakis@uoc.gr.
  • Papadogkonaki S; Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Crete, 71003, Greece. Electronic address: spapadogkonaki@hotmail.gr.
  • Filidou E; Laboratory of Pharmacology, School of Medicine, Democritus University of Thrace, Alexandroupolis, 68100, Greece. Electronic address: efilidou@hotmail.com.
  • Arvanitidis KI; Laboratory of Pharmacology, School of Medicine, Democritus University of Thrace, Alexandroupolis, 68100, Greece. Electronic address: karvanit@med.duth.gr.
  • Kolios G; Laboratory of Pharmacology, School of Medicine, Democritus University of Thrace, Alexandroupolis, 68100, Greece. Electronic address: gkolios@med.duth.gr.
  • Lamani M; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA, 02115, USA. Electronic address: manjubl123@gmail.com.
  • Makriyannis A; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA, 02115, USA. Electronic address: a.makriyannis@northeastern.edu.
  • Malamas MS; Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University, Boston, MA, 02115, USA. Electronic address: m.malamas@northeastern.edu.
  • Thermos K; Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Crete, 71003, Greece. Electronic address: thermos@uoc.gr.
Neuropharmacology ; 185: 108450, 2021 03 01.
Article in En | MEDLINE | ID: mdl-33450278
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retina / Arachidonic Acids / Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Endocannabinoids / Enzyme Inhibitors / Glycerides / Anti-Inflammatory Agents / Monoacylglycerol Lipases Limits: Animals Language: En Journal: Neuropharmacology Year: 2021 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retina / Arachidonic Acids / Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Endocannabinoids / Enzyme Inhibitors / Glycerides / Anti-Inflammatory Agents / Monoacylglycerol Lipases Limits: Animals Language: En Journal: Neuropharmacology Year: 2021 Document type: Article