Combined anti-PD-1 and anti-CTLA-4 checkpoint blockade: Treatment of melanoma and immune mechanisms of action.
Eur J Immunol
; 51(3): 544-556, 2021 03.
Article
in En
| MEDLINE
| ID: mdl-33450785
ABSTRACT
Cytotoxic T-lymphocyte associated protein-4 (CTLA-4) and the Programmed Death Receptor 1 (PD-1) are immune checkpoint molecules that are well-established targets of antibody immunotherapies for the management of malignant melanoma. The monoclonal antibodies, Ipilimumab, Pembrolizumab, and Nivolumab, designed to interfere with T cell inhibitory signals to activate immune responses against tumors, were originally approved as monotherapy. Treatment with a combination of immune checkpoint inhibitors may improve outcomes compared to monotherapy in certain patient groups and these clinical benefits may be derived from unique immune mechanisms of action. However, treatment with checkpoint inhibitor combinations also present significant clinical challenges and increased rates of immune-related adverse events. In this review, we discuss the potential mechanisms attributed to single and combined checkpoint inhibitor immunotherapies and clinical experience with their use.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
CTLA-4 Antigen
/
Programmed Cell Death 1 Receptor
/
Immune Checkpoint Inhibitors
/
Melanoma
/
Antibodies, Monoclonal
Limits:
Animals
/
Humans
Language:
En
Journal:
Eur J Immunol
Year:
2021
Document type:
Article
Affiliation country:
United kingdom