Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug.

Isgrò, Camilla; Sardanelli, Anna Maria; Palese, Luigi Leonardo

Isgrò, Camilla; Sardanelli, Anna Maria; Palese, Luigi Leonardo.

Affiliation

Isgrò C; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
Sardanelli AM; Department of Medicine, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy.
Palese LL; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.

Viruses ; 13(1)2021 Jan 13.

Article in En | MEDLINE | ID: mdl-33451132

Subject(s)

Antiviral Agents/pharmacology; Coronavirus 3C Proteases/antagonists & inhibitors; Ethacrynic Acid/pharmacology; Protease Inhibitors/pharmacokinetics; SARS-CoV-2/drug effects; Antiviral Agents/chemistry; Catalytic Domain; Coronavirus 3C Proteases/chemistry; Coronavirus 3C Proteases/metabolism; Databases, Factual; Drug Repositioning; Ethacrynic Acid/chemistry; Inhibitory Concentration 50; Molecular Docking Simulation; Protease Inhibitors/chemistry; SARS-CoV-2/enzymology

Key words

3C-like protease; 3CL protease; COVID-19; Mpro; SARS-CoV-2; coronavirus; drug repurposing; main protease; protease inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Ethacrynic Acid / Coronavirus 3C Proteases / SARS-CoV-2 Language: En Journal: Viruses Year: 2021 Document type: Article Affiliation country: Italy Country of publication: Switzerland

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