Application of DNA-Alkylating Pyrrole-Imidazole Polyamides for Cancer Treatment.

Maeda, Rina; Bando, Toshikazu; Sugiyama, Hiroshi

Maeda, Rina; Bando, Toshikazu; Sugiyama, Hiroshi.

Affiliation

Maeda R; Graduate School of Advanced Integrated Studies in Human Survivability, Kyoto University, Sakyo-ku, Kyoto, 606-8306, Japan.
Bando T; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto, 606-8502, Japan.
Sugiyama H; Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto, 606-8502, Japan.

Chembiochem ; 22(9): 1538-1545, 2021 05 04.

Article in En | MEDLINE | ID: mdl-33453075

Subject(s)

Antineoplastic Agents, Alkylating/chemistry; Imidazoles/chemistry; Nylons/chemistry; Pyrroles/chemistry; Animals; Antineoplastic Agents, Alkylating/therapeutic use; DNA/chemistry; Humans; Neoplasms/drug therapy; Neoplasms/pathology; Proto-Oncogene Proteins p21(ras)/genetics; Telomere/chemistry

Key words

DNA alkylation; DNA recognition; cancer; drug discovery; sequence-specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Antineoplastic Agents, Alkylating / Imidazoles / Nylons Limits: Animals / Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2021 Document type: Article Affiliation country: Japan Country of publication: Germany

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