Mild deprotection of the N-tert-butyloxycarbonyl (N-Boc) group using oxalyl chloride.
RSC Adv
; 10(40): 24017-24026, 2020.
Article
in En
| MEDLINE
| ID: mdl-33456769
ABSTRACT
We report a mild method for the selective deprotection of the N-Boc group from a structurally diverse set of compounds, encompassing aliphatic, aromatic, and heterocyclic substrates by using oxalyl chloride in methanol. The reactions take place under room temperature conditions for 1-4 h with yields up to 90%. This mild procedure was applied to a hybrid, medicinally active compound FC1, which is a novel dual inhibitor of IDO1 and DNA Pol gamma. A broader mechanism involving the electrophilic character of oxalyl chloride is postulated for this deprotection strategy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
RSC Adv
Year:
2020
Document type:
Article
Affiliation country:
United States