Mimicking SIV chimpanzee viral evolution toward HIV-1 during cross-species transmission.
J Med Primatol
; 49(5): 284-287, 2020 10.
Article
in En
| MEDLINE
| ID: mdl-33460210
ABSTRACT
HIV-1 evolved from SIV during cross-species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV-1 Group M using humanized mice. High viral loads, rapid CD4+ T-cell decline, and non-synonymous substitutions were identified throughout the viral genome suggesting viral adaptation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pan troglodytes
/
HIV-1
/
Simian Immunodeficiency Virus
/
Ape Diseases
/
Mutation
Limits:
Animals
Language:
En
Journal:
J Med Primatol
Year:
2020
Document type:
Article
Affiliation country:
United States