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Screening of Fabry Disease in Patients with Chest Pain Without Obstructive Coronary Artery Disease.
Hernández-Hernández, Aitor; Diez-López, Carles; Azevedo, Olga; Palomino-Doza, Julian; Alfonso, Fernando; Fuentes-Cañamero, María Eugenia; Mogollón Jiménez, María Victoria; Casanova Rodríguez, Carlos; Ruz, Aurora; Tirón, Coloma; Climent, Vicente; Garcia-Pavia, Pablo.
Affiliation
  • Hernández-Hernández A; Hospital Universitario Puerta de Hierro Majadahonda, CIBERCV, Manuel de Falla, 2. Majadahonda, 28222, Madrid, Spain.
  • Diez-López C; Hospital Universitario de Bellvitge, Barcelona, Spain.
  • Azevedo O; Hospital Senhora da Oliveira, Guimarães, Portugal.
  • Palomino-Doza J; Hospital Universitario 12 de Octubre, CIBERCV, Madrid, Spain.
  • Alfonso F; Hospital Universitario de La Princesa, Madrid, Spain.
  • Fuentes-Cañamero ME; Hospital Universitario de Badajoz, Badajoz, Spain.
  • Mogollón Jiménez MV; Complejo Hospitalario Universitario de Cáceres, Cáceres, Spain.
  • Casanova Rodríguez C; Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain.
  • Ruz A; Hospital La Serranía, Ronda, Spain.
  • Tirón C; Hospital Universitari Dr. Josep Trueta, CIBERCV, Girona, Spain.
  • Climent V; Hospital General Universitario de Alicante, Alicante, Spain.
  • Garcia-Pavia P; Hospital Universitario Puerta de Hierro Majadahonda, CIBERCV, Manuel de Falla, 2. Majadahonda, 28222, Madrid, Spain. pablogpavia@yahoo.es.
J Cardiovasc Transl Res ; 14(5): 948-950, 2021 10.
Article in En | MEDLINE | ID: mdl-33474682
ABSTRACT
Identification of Anderson-Fabry disease (AFD) in cardiac patients has been restricted so far to patients with left ventricular hypertrophy. Coronary microvascular dysfunction has been described in AFD with and without cardiac hypertrophy and may represent the only manifestation in AFD patients, offering a possible earlier diagnosis. We studied the prevalence of AFD in 663 patients with chest pain with normal or non-obstructive coronary arteries. The overall prevalence of AFD in this cohort was only 0.15% (1/663). AFD is not a frequent cause of chest pain without obstructive coronary artery disease and screening efforts should not be conducted in this patient population.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coronary Artery Disease / Fabry Disease / Angina Pectoris Type of study: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: J Cardiovasc Transl Res Journal subject: ANGIOLOGIA / CARDIOLOGIA Year: 2021 Document type: Article Affiliation country: Spain
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coronary Artery Disease / Fabry Disease / Angina Pectoris Type of study: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: J Cardiovasc Transl Res Journal subject: ANGIOLOGIA / CARDIOLOGIA Year: 2021 Document type: Article Affiliation country: Spain