ABT-751 Induces Multiple Anticancer Effects in Urinary Bladder Urothelial Carcinoma-Derived Cells: Highlighting the Induction of Cytostasis through the Inhibition of <i>SKP2</i> at Both Transcriptional and Post-Translational Levels.

Dehghanian, Seyedeh Zahra; Pan, Cheng-Tang; Lee, Jasmine Marianne; Shiue, Yow-Ling

ABT-751 Induces Multiple Anticancer Effects in Urinary Bladder Urothelial Carcinoma-Derived Cells: Highlighting the Induction of Cytostasis through the Inhibition of SKP2 at Both Transcriptional and Post-Translational Levels.

Dehghanian, Seyedeh Zahra; Pan, Cheng-Tang; Lee, Jasmine Marianne; Shiue, Yow-Ling.

Affiliation

Dehghanian SZ; Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, 70 Lienhai Rd, Kaohsiung 80424, Taiwan.
Pan CT; Institute of Precision Medicine, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Lee JM; Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Shiue YL; Johns Hopkins University, Baltimore, MD 21218, USA.

Int J Mol Sci ; 22(2)2021 Jan 19.

Article in En | MEDLINE | ID: mdl-33478005

Subject(s)

Carcinoma/drug therapy; Cyclin-Dependent Kinase Inhibitor p21/genetics; Cyclin-Dependent Kinase Inhibitor p27/genetics; S-Phase Kinase-Associated Proteins/genetics; Transcription, Genetic/drug effects; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Autophagy/drug effects; Carcinoma/genetics; Carcinoma/pathology; Cell Cycle Checkpoints/drug effects; Cell Proliferation/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Humans; Phosphatidylinositol 3-Kinase/genetics; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Mas; S-Phase Kinase-Associated Proteins/antagonists & inhibitors; Signal Transduction/drug effects; Sulfonamides/pharmacology; Urinary Bladder/drug effects; Urinary Bladder/pathology; Urothelium/drug effects; Urothelium/pathology

Key words

ABT-751; AKT; S-phase kinase associated protein 2; cyclin-dependent kinase inhibitors; cytostasis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Carcinoma / S-Phase Kinase-Associated Proteins / Cyclin-Dependent Kinase Inhibitor p21 / Cyclin-Dependent Kinase Inhibitor p27 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Taiwan Country of publication: Switzerland

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