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Universal toxin-based selection for precise genome engineering in human cells.
Li, Songyuan; Akrap, Nina; Cerboni, Silvia; Porritt, Michelle J; Wimberger, Sandra; Lundin, Anders; Möller, Carl; Firth, Mike; Gordon, Euan; Lazovic, Bojana; Sienska, Aleksandra; Pane, Luna Simona; Coelho, Matthew A; Ciotta, Giovanni; Pellegrini, Giovanni; Sini, Marcella; Xu, Xiufeng; Mitra, Suman; Bohlooly-Y, Mohammad; Taylor, Benjamin J M; Sienski, Grzegorz; Maresca, Marcello.
Affiliation
  • Li S; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. songyuan.li@astrazeneca.com.
  • Akrap N; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Cerboni S; Translational Science and Experimental Medicine, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Porritt MJ; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Wimberger S; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Lundin A; Department of Chemistry & Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
  • Möller C; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Firth M; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Gordon E; R&D Data Infrastructure & Tools, AstraZeneca, Cambridge, UK.
  • Lazovic B; Discovery Biology SWE, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Sienska A; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Pane LS; Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
  • Coelho MA; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Ciotta G; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Pellegrini G; Wellcome Sanger Institute, Cambridge, UK.
  • Sini M; Discovery Biology UK, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Xu X; CVRM pathology, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Mitra S; CVRM pathology, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Bohlooly-Y M; Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
  • Taylor BJM; Inserm UMR1277 CNRS UMR9020 - CANTHER, Institut pour la Recherche sur le Cancer de Lille, Lille, France.
  • Sienski G; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Maresca M; Discovery Biology UK, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Nat Commun ; 12(1): 497, 2021 01 21.
Article in En | MEDLINE | ID: mdl-33479216
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Engineering / CRISPR-Cas Systems / Heparin-binding EGF-like Growth Factor / Gene Editing / Mutation Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Sweden Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Engineering / CRISPR-Cas Systems / Heparin-binding EGF-like Growth Factor / Gene Editing / Mutation Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Sweden Country of publication: United kingdom