Outcomes of Intravenous Chemotherapy (Chemoreduction) for Retinoblastoma Based on Patient Age in 964 Eyes of 554 Patients.
Asia Pac J Ophthalmol (Phila)
; 10(4): 373-380, 2021 Jan 19.
Article
in En
| MEDLINE
| ID: mdl-33481399
ABSTRACT
PURPOSE:
To evaluate retinoblastoma control after intravenous chemotherapy (chemoreduction) by patient age at presentation.DESIGN:
Retrospective case series.METHODS:
This study included 964 eyes of 554 patients treated with chemoreduction at Ocular Oncology Service at Wills Eye Hospital. Patients received 6 monthly cycles of standard chemoreduction. Additional therapies for tumor control were performed as needed.RESULTS:
Of 964 eyes, a comparison by age group (<6 months vs. 6-12 months vs. 13-24 months vs. >24 months) revealed more advanced age group with higher frequency of group E tumor (15% vs. 25% vs. 32% vs. 39%, Pâ<â0.001). By treatment outcomes, complete tumor control was achieved with chemoreduction alone more often in less advanced age group (46% vs. 30% vs. 17% vs. 8%, Pâ<â0.001). Additional treatment after chemoreduction was needed more often in more advanced age group with external beam radiotherapy (EBRT; 9% vs. 16% vs. 20% vs. 15%, Pâ=â0.006) or enucleation (12% vs. 18% vs. 26% vs. 37%, Pâ<â0.001). Over time (1994-1998 vs. 1999-2003 vs. 2004-2008 vs. 2009-2013 vs. 2014-2019), the paradigm for additional required treatment after chemoreduction shifted toward less EBRT (27% vs. 24% vs. 14% vs. 7% vs. 2%, Pâ<â0.001) and more intra-arterial (0% vs. 0% vs. 1% vs. 25% vs. 48%, Pâ<â0.001) and intravitreal (0% vs. 0% vs. 3% vs. 10% vs. 20%, Pâ<â0.001) chemotherapy.CONCLUSIONS:
Chemoreduction is a safe and effective treatment method for patients with retinoblastoma, demonstrating the best tumor control in the younger age groups.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retinoblastoma
/
Retinal Neoplasms
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Child, preschool
/
Humans
/
Infant
Language:
En
Journal:
Asia Pac J Ophthalmol (Phila)
Year:
2021
Document type:
Article
Affiliation country:
Panama