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Integrin Linked Kinase (ILK) and its Role in Liver Pathobiology.
Martucci, Nicole; Michalopoulos, George K; Mars, Wendy M.
Affiliation
  • Martucci N; Department of Pathology, University of Pittsburgh School of MedicinePittsburgh, PAUSA.
  • Michalopoulos GK; Department of Pathology, University of Pittsburgh School of MedicinePittsburgh, PAUSA.
  • Mars WM; Department of Pathology, University of Pittsburgh School of MedicinePittsburgh, PAUSA.
Gene Expr ; 20(3): 201-207, 2021 06 11.
Article in En | MEDLINE | ID: mdl-33482930
ABSTRACT
Integrin linked kinase (ILK) is a vital signaling protein ubiquitously expressed throughout the body. It binds to intracellular integrins to help promote signaling related to cell adhesion, apoptosis, proliferation, migration, and a plethora of other common cellular functions. In this review, ILKs role in the liver is detailed. Studies have shown ILK to be a major participant in hepatic ECM organization, liver regeneration, insulin resistance, and hepatocellular carcinoma.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Liver / Liver Diseases Limits: Animals / Humans Language: En Journal: Gene Expr Journal subject: BIOLOGIA MOLECULAR Year: 2021 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Liver / Liver Diseases Limits: Animals / Humans Language: En Journal: Gene Expr Journal subject: BIOLOGIA MOLECULAR Year: 2021 Document type: Article