Cholestatic Hepatitis in Graves' Disease: A Diagnostic Challenge.
ACG Case Rep J
; 8(1): e00526, 2021 Jan.
Article
in En
| MEDLINE
| ID: mdl-33490298
ABSTRACT
Cholestatic hepatitis is a rare presentation of thyrotoxicosis potentially confused as an adverse effect of antithyroid therapy. We report a 37-year-old man with cholestatic hepatitis as an initial presentation of Graves' disease. Diagnostic evaluation demonstrated (i) elevated transaminases and alkaline phosphatase (R-factor value 2.6), and marked cholestasis (total bilirubin 17.3 mg/dL, direct bilirubin 9.4 mg/dL); (ii) negative hepatitis, viral, and autoimmune serologies; (iii) normal magnetic resonance cholangiopancreatography; (iv) liver biopsy with marked cholestasis and no fibrosis; (v) thyroid-stimulating hormone <0.01, fT4 (free thyroxine) 1.5, fT4 (free triiodothyronine) 4.3 and positive thyroid-stimulating immunoglobulins. Radioiodine uptake scan confirmed Graves' disease. Clinical resolution was achieved with propranolol, prednisone, methimazole, and thyroidectomy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Diagnostic_studies
Language:
En
Journal:
ACG Case Rep J
Year:
2021
Document type:
Article
Affiliation country:
Moldova