Pre-imaginal exposure to Oberon® disrupts fatty acid composition, cuticular hydrocarbon profile and sexual behavior in Drosophila melanogaster adults.
Comp Biochem Physiol C Toxicol Pharmacol
; 243: 108981, 2021 May.
Article
in En
| MEDLINE
| ID: mdl-33493665
ABSTRACT
Oberon® is a commercial formulation of spiromesifen, a pesticide inhibitor of lipid biosynthesis via acetyl CoA carboxylase, widely used in agricultural crop protection. However, its mode of action requires further analysis. We currently examined the effect of this product on Drosophila melanogaster as a non-target and model organism. Different concentrations of spiromesifen were administered by ingestion (and contact) during pre-imaginal development, and we evaluated its delayed action on adults. Our results suggest that spiromesifen induced insecticidal activity on D. melanogaster. Moreover, spiromesifen treatment significantly increased the duration of larval and pupal development at all tested concentrations while it shortened longevity in exposed males as compared to control males. Also, pre-imaginal exposure to spiromesifen quantitatively affected fatty acids supporting its primary mode of action on lipid synthesis. In addition, this product was found to modify cuticular hydrocarbon profiles in exposed female and male flies as well as their sexual behavior and reproductive capacity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sexual Behavior, Animal
/
Spiro Compounds
/
Drosophila melanogaster
/
Fatty Acids
/
Animal Scales
/
Insecticides
Limits:
Animals
Language:
En
Journal:
Comp Biochem Physiol C Toxicol Pharmacol
Journal subject:
FARMACOLOGIA
/
TOXICOLOGIA
Year:
2021
Document type:
Article
Affiliation country:
France