Microbiota control of maternal behavior regulates early postnatal growth of offspring.
Sci Adv
; 7(5)2021 01.
Article
in En
| MEDLINE
| ID: mdl-33514556
ABSTRACT
Maternal behavior is necessary for optimal development and growth of offspring. The intestinal microbiota has emerged as a critical regulator of growth and development in the early postnatal period life. Here, we describe the identification of an intestinal Escherichia coli strain that is pathogenic to the maternal-offspring system during the early postnatal stage of life and results in growth stunting of the offspring. However, rather than having a direct pathogenic effect on the infant, we found that this particular E. coli strain was pathogenic to the dams by interfering with the maturation of maternal behavior. This resulted in malnourishment of the pups and impaired insulin-like growth factor 1 (IGF-1) signaling, leading to the consequential stunted growth. Our work provides a new understanding of how the microbiota regulates postnatal growth and an additional variable that must be considered when studying the regulation of maternal behavior.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Microbiota
/
Gastrointestinal Microbiome
Type of study:
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Sci Adv
Year:
2021
Document type:
Article
Affiliation country:
United States