Synthesis of Five-Membered Cyclic Guanidines via Cascade [3 + 2] Cycloaddition of α-Haloamides with Organo-cyanamides.
J Org Chem
; 86(4): 3546-3554, 2021 02 19.
Article
in En
| MEDLINE
| ID: mdl-33538590
ABSTRACT
The convenient preparation of N2-unprotected five-membered cyclic guanidines was achieved through a cascade [3 + 2] cycloaddition between organo-cyanamides and α-haloamides under mild conditions in good to excellent yields (up to 99%). The corresponding cyclic guanidines could be easily transformed into hydantoins via hydrolysis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cyanamide
/
Guanidines
Language:
En
Journal:
J Org Chem
Year:
2021
Document type:
Article
Affiliation country:
China