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Gut microbiota metabolites in autistic children: An epigenetic perspective.
Sabit, Hussein; Tombuloglu, Huseyin; Rehman, Suriya; Almandil, Noor B; Cevik, Emre; Abdel-Ghany, Shaimaa; Rashwan, Sanaa; Abasiyanik, Mustafa Fatih; Yee Waye, Mary Miu.
Affiliation
  • Sabit H; Department of Genetics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441 Saudi Arabia.
  • Tombuloglu H; Department of Genetics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441 Saudi Arabia.
  • Rehman S; Department of Epidemic Diseases, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441 Saudi Arabia.
  • Almandil NB; Department of Clinical Pharmacy Research, Institute for Research and Medical Consultation (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441 Saudi Arabia.
  • Cevik E; Department of Genetics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441 Saudi Arabia.
  • Abdel-Ghany S; Department of Environmental Biotechnology, College of Biotechnology, Misr University for Science and Technology, P. O. Box 77, Giza, Egypt.
  • Rashwan S; Pediatrics Department, Madinat Zayed Hospital, SEHA, Abu Dhabi, United Arab Emirates.
  • Abasiyanik MF; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA.
  • Yee Waye MM; Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL, 60637, USA.
Heliyon ; 7(1): e06105, 2021 Jan.
Article in En | MEDLINE | ID: mdl-33553761
Gut microbiota has become an issue of great importance recently due to its major role in autism spectrum disorder (ASD). Over the past three decades, there has been a sustained research activity focused to explain the actual mechanism by which gut microbiota triggers/develops autism. Several genetic and epigenetic factors are involved in this disorder, with epigenetics being the most active area of research. Although the constant investigation and advancements, epigenetic implications in ASD still need a deeper functional/causal analysis. In this review, we describe the major gut microbiota metabolites and how they induce epigenetic changes in ASD along with interactions through the gut-brain axis.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Heliyon Year: 2021 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Heliyon Year: 2021 Document type: Article Country of publication: United kingdom