From diabetes to renal aging: the therapeutic potential of adiponectin.
J Physiol Biochem
; 77(2): 205-214, 2021 May.
Article
in En
| MEDLINE
| ID: mdl-33555532
ABSTRACT
Nowadays, the complications related to diabetes, such as nephropathy, cardiovascular problems, and aging, are highly being considered. Renal cell aging is affected by various mechanisms of inflammation, oxidative stress, and basement membrane thickening, which are significant causes of renal dysfunction in diabetes. Due to recent studies, adiponectin plays a key role in diabetes-related kidney diseases as a fat-derived hormone. In diabetes, reduced adiponectin levels are associated to renal cell aging. Oxidative stress and related signaling pathways are the main routes in which adiponectin may be effective to decline diabetes-associated aging. Therefore, adiponectin signaling in target tissues becomes one of the research areas of interest in metabolism and clinical medicine. Studies on adiponectin signaling will increase our understanding of adiponectin role in diabetes-linked diseases as well as shortening life span conditions which may guide the design of antidiabetic and anti-aging drugs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 2
/
Diabetic Nephropathies
/
Adiponectin
/
Receptors, Adiponectin
/
Obesity
Limits:
Animals
/
Humans
Language:
En
Journal:
J Physiol Biochem
Journal subject:
BIOQUIMICA
/
FISIOLOGIA
Year:
2021
Document type:
Article
Affiliation country:
Iran