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Interference with TGFß1-Mediated Inflammation and Fibrosis Underlies Reno-Protective Effects of the CB1 Receptor Neutral Antagonists AM6545 and AM4113 in a Rat Model of Metabolic Syndrome.
Eid, Basma G; Neamatallah, Thikryat; Hanafy, Abeer; El-Bassossy, Hany M; Binmahfouz, Lenah; Aldawsari, Hibah M; Hasan, Atif; El-Aziz, Gamal Abd; Vemuri, Kiran; Makriyannis, Alexandros.
Affiliation
  • Eid BG; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • Neamatallah T; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • Hanafy A; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • El-Bassossy HM; Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
  • Binmahfouz L; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
  • Aldawsari HM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • Hasan A; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • El-Aziz GA; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
  • Vemuri K; Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • Makriyannis A; Center for Drug Discovery, Northeastern University, Boston, MA 02115, USA.
Molecules ; 26(4)2021 Feb 06.
Article in En | MEDLINE | ID: mdl-33562080
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Morpholines / Metabolic Syndrome / Receptor, Cannabinoid, CB1 / Transforming Growth Factor beta1 / Kidney Type of study: Prognostic_studies Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Document type: Article Affiliation country: Saudi Arabia Country of publication: Switzerland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Morpholines / Metabolic Syndrome / Receptor, Cannabinoid, CB1 / Transforming Growth Factor beta1 / Kidney Type of study: Prognostic_studies Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Document type: Article Affiliation country: Saudi Arabia Country of publication: Switzerland