Rab27a Contributes to Cathepsin S Secretion in Lacrimal Gland Acinar Cells.

Fu, Runzhong; Edman, Maria C; Hamm-Alvarez, Sarah F

Fu, Runzhong; Edman, Maria C; Hamm-Alvarez, Sarah F.

Affiliation

Fu R; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.
Edman MC; Department of Ophthalmology, Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Hamm-Alvarez SF; Department of Ophthalmology, Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

Int J Mol Sci ; 22(4)2021 Feb 05.

Article in En | MEDLINE | ID: mdl-33562815

Subject(s)

Cathepsins/metabolism; Lacrimal Apparatus/cytology; Sjogren's Syndrome/metabolism; rab27 GTP-Binding Proteins/metabolism; Acinar Cells/cytology; Acinar Cells/metabolism; Acinar Cells/pathology; Animals; Carbachol/pharmacology; Cells, Cultured; Disease Models, Animal; Endosomes/metabolism; Lacrimal Apparatus/metabolism; Lacrimal Apparatus/pathology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; rab27 GTP-Binding Proteins/genetics

Key words

Cathepsin S; Rab27a; Sjögren's syndrome; acinar cells; endolysosomal secretion; lacrimal gland; rab proteins; regulated secretion

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sjogren's Syndrome / Cathepsins / Rab27 GTP-Binding Proteins / Lacrimal Apparatus Limits: Animals Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: United States Country of publication: Switzerland

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