Identification of epigenetic memory candidates associated with gestational age at birth through analysis of methylome and transcriptional data.
Sci Rep
; 11(1): 3381, 2021 02 09.
Article
in En
| MEDLINE
| ID: mdl-33564054
ABSTRACT
Preterm birth is known to be associated with chronic disease risk in adulthood whereby epigenetic memory may play a mechanistic role in disease susceptibility. Gestational age (GA) is the most important prognostic factor for preterm infants, and numerous DNA methylation alterations associated with GA have been revealed by epigenome-wide association studies. However, in human preterm infants, whether the methylation changes relate to transcription in the fetal state and persist after birth remains to be elucidated. Here, we identified 461 transcripts associated with GA (range 23-41 weeks) and 2093 candidate CpG sites for GA-involved epigenetic memory through analysis of methylome (110 cord blood and 47 postnatal blood) and transcriptional data (55 cord blood). Moreover, we discovered the trends of chromatin state, such as polycomb-binding, among these candidate sites. Fifty-four memory candidate sites showed correlation between methylation and transcription, and the representative corresponding gene was UCN, which encodes urocortin.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gestational Age
/
DNA Methylation
/
Databases, Nucleic Acid
/
Epigenesis, Genetic
/
Epigenome
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
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Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
Sci Rep
Year:
2021
Document type:
Article
Affiliation country:
Japan