Minocycline and Doxycycline: More Than Antibiotics.
Curr Mol Pharmacol
; 14(6): 1046-1065, 2021.
Article
in En
| MEDLINE
| ID: mdl-33568043
ABSTRACT
Minocycline and doxycycline both are second-generation tetracycline antibiotics with similar chemical structures and comparable antibacterial spectrum. Minocycline has also emerged as the tetracycline of choice for multidrug-resistant Acinetobacter baumannii infections, although doxycycline has also shown the activity. Minocycline showed promising results in experimental neurology, which was due to its highly lipophilic nature. It is clinically safe and effective adjunct to antipsychotic medications. The objective of the current review is to provide clinical and preclinical, non-antibiotic uses of minocycline as well as doxycycline. Relevant literature covers antibiotic actions but is more specifically concerned with the non-antibiotic biological aspect of tetracyclines. Non-antibiotic biological effects for both the antibiotics were identified through searching relevant databases including PubMed, Scopus, and Web of Science up to 2020, using the keywords 'minocycline and doxycycline'. Anti-inflammatory, anti-oxidant, anti-apoptotic neuroprotective, immunomodulatory and the number of other non-antibiotic effects were compiled for minocycline and doxycycline.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Doxycycline
/
Minocycline
Language:
En
Journal:
Curr Mol Pharmacol
Journal subject:
FARMACOLOGIA
Year:
2021
Document type:
Article
Affiliation country:
India