Glycans in Immunologic Health and Disease.
Annu Rev Immunol
; 39: 511-536, 2021 04 26.
Article
in En
| MEDLINE
| ID: mdl-33577348
ABSTRACT
The surfaces of all living organisms and most secreted proteins share a common feature They are glycosylated. As the outermost-facing molecules, glycans participate in nearly all immunological processes, including driving host-pathogen interactions, immunological recognition and activation, and differentiation between self and nonself through a complex array of pathways and mechanisms. These fundamental immunologic roles are further cast into sharp relief in inflammatory, autoimmune, and cancer disease states in which immune regulation goes awry. Here, we review the broad impact of glycans on the immune system and discuss the changes and clinical opportunities associated with the onset of immunologic disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polysaccharides
/
Host-Pathogen Interactions
Limits:
Animals
/
Humans
Language:
En
Journal:
Annu Rev Immunol
Year:
2021
Document type:
Article