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Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia.
de Groot, Anne P; Saito, Yoriko; Kawakami, Eiryo; Hashimoto, Mari; Aoki, Yuki; Ono, Rintaro; Ogahara, Ikuko; Fujiki, Saera; Kaneko, Akiko; Sato, Kaori; Kajita, Hiroshi; Watanabe, Takashi; Takagi, Masatoshi; Tomizawa, Daisuke; Koh, Katsuyoshi; Eguchi, Mariko; Ishii, Eiichi; Ohara, Osamu; Shultz, Leonard D; Mizutani, Shuki; Ishikawa, Fumihiko.
Affiliation
  • de Groot AP; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Saito Y; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Kawakami E; Healthcare and Medical Data Driven AI based Predictive Reasoning Development Unit, RIKEN Medical Sciences Innovation Hub Program, Yokohama, Japan.
  • Hashimoto M; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Aoki Y; Department of Pediatrics, National Cancer Center Hospital, Tokyo, Japan.
  • Ono R; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Ogahara I; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Fujiki S; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Kaneko A; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Sato K; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Kajita H; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
  • Watanabe T; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Takagi M; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
  • Tomizawa D; Division of Leukaemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
  • Koh K; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
  • Eguchi M; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.
  • Ishii E; Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.
  • Ohara O; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Kazusa DNA Research Institute, Kisarazu, Chiba, Japan.
  • Shultz LD; The Jackson Laboratory, Bar Harbor, USA.
  • Mizutani S; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
  • Ishikawa F; Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. Electronic address: fumihiko.ishikawa@riken.jp.
EBioMedicine ; 64: 103235, 2021 Feb.
Article in En | MEDLINE | ID: mdl-33581643
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Rearrangement / Histone-Lysine N-Methyltransferase / Apoptosis / Drug Resistance, Neoplasm / Myeloid-Lymphoid Leukemia Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: EBioMedicine Year: 2021 Document type: Article Affiliation country: Japan Country of publication: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Rearrangement / Histone-Lysine N-Methyltransferase / Apoptosis / Drug Resistance, Neoplasm / Myeloid-Lymphoid Leukemia Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: EBioMedicine Year: 2021 Document type: Article Affiliation country: Japan Country of publication: Netherlands