Synthesis of 2-nitro aniline derivative of 3, 4, 5-trihydroxybenzoic acid, its metal complexes, characterization and bioassay.
Pak J Pharm Sci
; 33(4): 1451-1458, 2020 Jul.
Article
in En
| MEDLINE
| ID: mdl-33583774
ABSTRACT
Present research work discloses new and novel synthesis of metal complexes (Fe, Cu, Zn, Sb and Sn) of 3, 4, 5-trihydroxybenzoic acid derivative containing aniline moiety with substitution at C-7 position of 3, 4, 5-trihydroxybenzoic acid in order to enhance its biological activities by coupling therapeutic values of transition metals as well. In vitro antibacterial and antifungal activities of these compounds has been performed by using agar diffusion method against different bacterial and fungal strains. The free radical scavenging assay was performed by using 2, 2-diphenyl-1-picryl-hydrazyl (DPPH). Cytotoxic action of compounds was assessed by utilizing the standard MTT (3-[4, 5-dimethylthiazole-2-yl]-2, 5-diphenyl-tetrazolium bromide) colorimetric assay. The structure of newly synthesized complexes were confirmed by using IR and 1HNMR spectral analysis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coordination Complexes
/
Aniline Compounds
/
Metals
Limits:
Humans
Language:
En
Journal:
Pak J Pharm Sci
Journal subject:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Year:
2020
Document type:
Article
Affiliation country:
Pakistan