Inheritance of diabetes mellitus in Keeshond dogs.
Am J Vet Res
; 49(3): 428-31, 1988 Mar.
Article
in En
| MEDLINE
| ID: mdl-3358555
ABSTRACT
The genetic aspects of inherited, insulin-dependent diabetes mellitus of Keeshond dogs were studied retrospectively and in a prospective mating program. The symbol dm was used to designate the gene that causes hypoplasia of the islets of Langerhans. The retrospective study disclosed 4 diabetic dogs; prospective outcross, backcross, and inbred matings disclosed 49 diabetic dogs. Outcrossing demonstrated that the diabetic phenotype was displayed readily against a genetic background of a breed other than the Keeshond. In dogs with the dm/dm genotype, onset of diabetes was most frequent before the dog was 6 months old, but did occur in some older dogs. The dm genotype was best described as autosomal recessive.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 1
/
Dog Diseases
Type of study:
Observational_studies
Limits:
Animals
Language:
En
Journal:
Am J Vet Res
Year:
1988
Document type:
Article