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Parallel genome-wide RNAi screens identify lymphocyte-specific protein tyrosine kinase (LCK) as a targetable vulnerability of cell proliferation and chemoresistance in nasopharyngeal carcinoma.
Liew, Kitson; Yu, Gibson Qi Sheng; Wei Pua, Lesley Jia; Wong, Li Zhe; Tham, Shiau Ying; Hii, Ling-Wei; Lim, Wei-Meng; OuYong, Brian Ming; Looi, Chin King; Mai, Chun-Wai; Fei-Lei Chung, Felicia; Tan, Lu Ping; Ahmad, Munirah; Soo-Beng Khoo, Alan; Leong, Chee-Onn.
Affiliation
  • Liew K; Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, Malaysia.
  • Yu GQS; School of Medicine, International Medical University, Kuala Lumpur, Malaysia.
  • Wei Pua LJ; Center for Cancer and Stem Cell Research, Institute for Research, Development and Innovation (IRDI), International Medical University, Kuala Lumpur, Malaysia; School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia; School of Pharmacy, International Medical Universit
  • Wong LZ; Center for Cancer and Stem Cell Research, Institute for Research, Development and Innovation (IRDI), International Medical University, Kuala Lumpur, Malaysia; School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia.
  • Tham SY; Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, Malaysia.
  • Hii LW; Center for Cancer and Stem Cell Research, Institute for Research, Development and Innovation (IRDI), International Medical University, Kuala Lumpur, Malaysia; School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia; School of Pharmacy, International Medical Universit
  • Lim WM; Center for Cancer and Stem Cell Research, Institute for Research, Development and Innovation (IRDI), International Medical University, Kuala Lumpur, Malaysia; School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
  • OuYong BM; School of Medicine, International Medical University, Kuala Lumpur, Malaysia.
  • Looi CK; Center for Cancer and Stem Cell Research, Institute for Research, Development and Innovation (IRDI), International Medical University, Kuala Lumpur, Malaysia; School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia.
  • Mai CW; Center for Cancer and Stem Cell Research, Institute for Research, Development and Innovation (IRDI), International Medical University, Kuala Lumpur, Malaysia; State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Department of Urology, Ren Ji Hospital,
  • Fei-Lei Chung F; Mechanisms of Carcinogenesis Section (MCA), Epigenetics Group (EGE), International Agency for Research on Cancer World Health Organization, Lyon CEDEX 08, France.
  • Tan LP; Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, Malaysia.
  • Ahmad M; Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, Malaysia.
  • Soo-Beng Khoo A; Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Selangor, Malaysia; Center for Cancer and Stem Cell Research, Institute for Research, Development and Innovation (IRDI), International Medical Univ
  • Leong CO; Center for Cancer and Stem Cell Research, Institute for Research, Development and Innovation (IRDI), International Medical University, Kuala Lumpur, Malaysia; School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia. Electronic address: cheeonn_leong@imu.edu.my.
Cancer Lett ; 504: 81-90, 2021 04 28.
Article in En | MEDLINE | ID: mdl-33587980
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Lymphocytes / Nasopharyngeal Neoplasms / Drug Resistance, Neoplasm / RNA Interference / Cell Proliferation / Nasopharyngeal Carcinoma / Antineoplastic Agents Limits: Humans Language: En Journal: Cancer Lett Year: 2021 Document type: Article Affiliation country: Malaysia Country of publication: Ireland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Lymphocytes / Nasopharyngeal Neoplasms / Drug Resistance, Neoplasm / RNA Interference / Cell Proliferation / Nasopharyngeal Carcinoma / Antineoplastic Agents Limits: Humans Language: En Journal: Cancer Lett Year: 2021 Document type: Article Affiliation country: Malaysia Country of publication: Ireland