A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants.
Elife
; 102021 02 16.
Article
in En
| MEDLINE
| ID: mdl-33588989
ABSTRACT
Influenza virus has a high mutation rate, such that within one host different viral variants can emerge. Evidence suggests that influenza virus variants are more prevalent in pregnant and/or obese individuals due to their impaired interferon response. We have recently shown that the non-allergic, paucigranulocytic subtype of asthma is associated with impaired type I interferon production. Here, we seek to address if this is associated with an increased emergence of influenza virus variants. Compared to controls, mice with paucigranulocytic asthma had increased disease severity and an increased emergence of influenza virus variants. Specifically, PB1 mutations exclusively detected in asthmatic mice were associated with increased polymerase activity. Furthermore, asthmatic host-derived virus led to increased disease severity in wild-type mice. Taken together, these data suggest that at least a subset of patients with asthma may be more susceptible to severe influenza and may be a possible source of new influenza virus variants.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Orthomyxoviridae Infections
/
Influenza A Virus, H1N1 Subtype
Limits:
Animals
Language:
En
Journal:
Elife
Year:
2021
Document type:
Article
Affiliation country:
Australia