Meta-analysis of P53 expression and sensitivity to platinum-based chemotherapy in patients with non-small cell lung cancer.
Medicine (Baltimore)
; 100(5): e24194, 2021 Feb 05.
Article
in En
| MEDLINE
| ID: mdl-33592864
ABSTRACT
BACKGROUND:
The relationship between p53 expression and chemosensitivity of non-small cell lung cancer (NSCLC) is unclear. This study aims to explore the correlation between p53 expression and sensitivity to platinum-based chemotherapy in patients with NSCLC.METHODS:
Pubmed, Web of Science, EMBASE, CNKI, China Wanfang databases were searched for studies on the relationship between the p53 expression and the chemosensitivity to platinum drugs in patients with NSCLC. The last search time was May 2020. Stata 15.0 software was used for statistical analysis.RESULTS:
A total of 21 studies were included, covering 1387 patients in total. The results showed that the pooled ORâ=â1.55 (95%CI 1.05â¼2.29, Pâ<â.05), for Asian population, the pooled ORâ=â1.67 (95%CI 0.95â¼3.09, Pâ>â.05), for Caucasian population, the pooled ORâ=â1.34 (95%CI 0.74â¼2.43), there was no significant difference between Asian and Caucasian. The results of subgroup analysis of publication year showed that, the pooled ORâ=â2.07 (95%CI 1.39â¼3.07, Pâ<â.01), the heterogeneity among the studies decreased remarkably after 2005. The subgroup analysis of advanced patients showed that the pooled ORâ=â1.93 (95%CI 1.27â¼2.93), the difference was statistically significant.CONCLUSION:
Patients with p53 negative expression is more sensitive to platinum-based chemotherapy than those with p53 positive expression in NSCLC, especially in advanced NSCLC.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tumor Suppressor Protein p53
/
Platinum Compounds
/
Carcinoma, Non-Small-Cell Lung
/
Lung Neoplasms
Type of study:
Diagnostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Medicine (Baltimore)
Year:
2021
Document type:
Article
Affiliation country:
China