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pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation.
Koshiyama, Tomomi; Inoue, Yuki; Asada, Sana; Kawahara, Koki; Ide, Shogo; Yasuhara, Kazuma; Ohba, Masaaki.
Affiliation
  • Koshiyama T; Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, 1-1-1, Noji-higashi, Kusatsu, Shiga 525-8577, Japan. koshi@fc.ritsumei.ac.jp.
  • Inoue Y; Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. ohba@chem.kyushu-univ.jp.
  • Asada S; Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. ohba@chem.kyushu-univ.jp.
  • Kawahara K; Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. ohba@chem.kyushu-univ.jp.
  • Ide S; Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. ohba@chem.kyushu-univ.jp.
  • Yasuhara K; Division of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
  • Ohba M; Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. ohba@chem.kyushu-univ.jp.
Chem Commun (Camb) ; 57(23): 2895-2898, 2021 Mar 18.
Article in En | MEDLINE | ID: mdl-33606865
ABSTRACT
Amphotericin B incorporating 2,2'-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca2+ ion permeability with a selective response to Cu2+ ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amphotericin B / Coordination Complexes / Ion Channels / Lipid Bilayers Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amphotericin B / Coordination Complexes / Ion Channels / Lipid Bilayers Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: Japan