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Short- and medium-term exposures of diazepam induce metabolomic alterations associated with the serotonergic, dopaminergic, adrenergic and aspartic acid neurotransmitter systems in zebrafish (Danio rerio) embryos/larvae.
Markin, Pavel A; Brito, Alex; Moskaleva, Natalia E; Tagliaro, Franco; Tarasov, Vadim V; La Frano, Michael R; Savitskii, Mark V; Appolonova, Svetlana A.
Affiliation
  • Markin PA; Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; PhD Program in Nanosciences and Advanced Technologies, University of Verona, Verona, Italy; I.M. Sechenov First Moscow
  • Brito A; Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
  • Moskaleva NE; Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; World-Class Research Center "Digital Biodesign and Personalized Healthcare", I.M. Sechenov First Moscow State Medical U
  • Tagliaro F; Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; Unit of Forensic Medicine, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
  • Tarasov VV; I.M. Sechenov First Moscow State Medical University, Russia.
  • La Frano MR; Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, CA, USA; Cal Poly Metabolomics Service Center, California Polytechnic State University, San Luis Obispo, CA, USA.
  • Savitskii MV; Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; I.M. Sechenov First Moscow State Medical University, Russia.
  • Appolonova SA; Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia. Electronic address: svetlana.appolonova@labworks.ru.
Comp Biochem Physiol Part D Genomics Proteomics ; 38: 100816, 2021 06.
Article in En | MEDLINE | ID: mdl-33610025
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zebrafish / Aspartic Acid / Neurotransmitter Agents / Diazepam / Hypnotics and Sedatives Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Comp Biochem Physiol Part D Genomics Proteomics Journal subject: BIOLOGIA / GENETICA Year: 2021 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zebrafish / Aspartic Acid / Neurotransmitter Agents / Diazepam / Hypnotics and Sedatives Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Comp Biochem Physiol Part D Genomics Proteomics Journal subject: BIOLOGIA / GENETICA Year: 2021 Document type: Article