Novel phospho-specific monoclonal antibodies reveal differential regulation of tyrosine phosphorylation within the immunoreceptor tyrosine-based activation motif of the Fc receptor Î³ subunit leading to fine tuning of Syk activation.

Yamashita, Yumi; Yamashita, Toshiyuki

Yamashita, Yumi; Yamashita, Toshiyuki.

Affiliation

Yamashita Y; Department of Immunology, School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima, 963-8611, Japan.
Yamashita T; Department of Immunology, School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima, 963-8611, Japan. Electronic address: t-yamashita@pha.ohu-u.ac.jp.

Biochem Biophys Res Commun ; 547: 89-95, 2021 04 02.

Article in En | MEDLINE | ID: mdl-33610045

Subject(s)

Antibodies, Monoclonal/metabolism; Antibodies, Phospho-Specific/metabolism; Immunoreceptor Tyrosine-Based Activation Motif; Mast Cells/immunology; Receptors, IgG/metabolism; Syk Kinase/metabolism; Tyrosine/metabolism; Animals; Antibodies, Monoclonal/immunology; Antibodies, Phospho-Specific/immunology; Cells, Cultured; Mast Cells/metabolism; Mice, Inbred C57BL; Phosphorylation; Receptors, IgG/chemistry; Signal Transduction; Tyrosine/chemistry

Key words

FcÎµRI; ITAM; Lyn; Mast cell; Phospho-specific antibody; Syk

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tyrosine / Receptors, IgG / Antibodies, Phospho-Specific / Immunoreceptor Tyrosine-Based Activation Motif / Syk Kinase / Mast Cells / Antibodies, Monoclonal Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2021 Document type: Article Affiliation country: Japan Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google