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The delta isoform of phosphatidylinositol-3-kinase predominates in chronic myelomonocytic leukemia and can be targeted effectively with umbralisib and ruxolitinib.
Villaume, Matthew T; Arrate, M Pia; Ramsey, Haley E; Sunthankar, Kathryn I; Jenkins, Matthew T; Moyo, Tamara K; Smith, Brianna N; Fischer, Melissa A; Childress, Merrida A; Gorska, Agnieszka E; Ferrell, P Brent; Savona, Michael R.
Affiliation
  • Villaume MT; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN.
  • Arrate MP; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
  • Ramsey HE; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN.
  • Sunthankar KI; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
  • Jenkins MT; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Moyo TK; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
  • Smith BN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN.
  • Fischer MA; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN.
  • Childress MA; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN.
  • Gorska AE; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
  • Ferrell PB; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, TN; Vanderbilt-Ingram Cancer Center, Vanderbilt Universi
  • Savona MR; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, TN; Vanderbilt-Ingram Cancer Center, Vanderbilt Universi
Exp Hematol ; 97: 57-65.e5, 2021 05.
Article in En | MEDLINE | ID: mdl-33617893
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Leukemia, Myelomonocytic, Chronic / Class I Phosphatidylinositol 3-Kinases / Phosphoinositide-3 Kinase Inhibitors / Heterocyclic Compounds, 4 or More Rings Limits: Humans Language: En Journal: Exp Hematol Year: 2021 Document type: Article Affiliation country: Tunisia Country of publication: Netherlands
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Leukemia, Myelomonocytic, Chronic / Class I Phosphatidylinositol 3-Kinases / Phosphoinositide-3 Kinase Inhibitors / Heterocyclic Compounds, 4 or More Rings Limits: Humans Language: En Journal: Exp Hematol Year: 2021 Document type: Article Affiliation country: Tunisia Country of publication: Netherlands