A fast and high-sensitivity liquid chromatography-tandem mass spectrometry method combined with in vivo microdialysis for quantification of meropenem in rabbits with sepsis under the simultaneous infusion of total parenteral nutrition: Application to a pharmacokinetic study.

Fei, Yibo; Wu, Shengyuan; Wang, Yuanyuan; Shen, Fuming; Fan, Guorong

Fei, Yibo; Wu, Shengyuan; Wang, Yuanyuan; Shen, Fuming; Fan, Guorong.

Affiliation

Fei Y; Tongji University School of Medicine, Shanghai, China.
Wu S; Department of Pharmacy, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Wang Y; Tongji University School of Medicine, Shanghai, China.
Shen F; Tongji University School of Medicine, Shanghai, China.
Fan G; Department of Pharmacy, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Biomed Chromatogr ; 35(7): e5100, 2021 Jul.

Article in En | MEDLINE | ID: mdl-33624854

Subject(s)

Chromatography, Liquid/methods; Meropenem/blood; Microdialysis; Parenteral Nutrition, Total; Sepsis/metabolism; Administration, Intravenous; Animals; Anti-Bacterial Agents/administration & dosage; Anti-Bacterial Agents/blood; Anti-Bacterial Agents/pharmacokinetics; Drug Monitoring; Linear Models; Male; Meropenem/administration & dosage; Meropenem/pharmacokinetics; Rabbits; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry/methods

Key words

liquid chromatography-tandem mass spectrometry; meropenem; microdialysis; sepsis; total parenteral nutrition

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatography, Liquid / Parenteral Nutrition, Total / Microdialysis / Sepsis / Meropenem Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Biomed Chromatogr Year: 2021 Document type: Article Affiliation country: China

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