Targeting cell-intrinsic metabolism for antifibrotic therapy.

Gilgenkrantz, Helene; Mallat, Ariane; Moreau, Richard; Lotersztajn, Sophie

Gilgenkrantz, Helene; Mallat, Ariane; Moreau, Richard; Lotersztajn, Sophie.

Affiliation

Gilgenkrantz H; Université de Paris, INSERM, U1149, CNRS, ERL 8252, Centre de Recherche sur l'Inflammation (CRI), Laboratoire d'Excellence Inflamex, F-75018 Paris, France.
Mallat A; Université de Paris, INSERM, U1149, CNRS, ERL 8252, Centre de Recherche sur l'Inflammation (CRI), Laboratoire d'Excellence Inflamex, F-75018 Paris, France.
Moreau R; Université de Paris, INSERM, U1149, CNRS, ERL 8252, Centre de Recherche sur l'Inflammation (CRI), Laboratoire d'Excellence Inflamex, F-75018 Paris, France.
Lotersztajn S; Université de Paris, INSERM, U1149, CNRS, ERL 8252, Centre de Recherche sur l'Inflammation (CRI), Laboratoire d'Excellence Inflamex, F-75018 Paris, France. Electronic address: Sophie.lotersztajn@inserm.fr.

J Hepatol ; 74(6): 1442-1454, 2021 06.

Article in En | MEDLINE | ID: mdl-33631228

Subject(s)

Antifibrotic Agents/therapeutic use; Hepatic Stellate Cells/metabolism; Hepatocytes/metabolism; Liver Cirrhosis/drug therapy; Liver Cirrhosis/metabolism; Lymphocytes/metabolism; Macrophages/metabolism; Non-alcoholic Fatty Liver Disease/drug therapy; Non-alcoholic Fatty Liver Disease/metabolism; Signal Transduction/drug effects; Animals; Antifibrotic Agents/pharmacology; Cholesterol/metabolism; Glycolysis/drug effects; Humans; Lipogenesis/drug effects; Liver Cirrhosis/complications; Liver Cirrhosis/immunology; Lymphocytes/immunology; Macrophages/immunology; Non-alcoholic Fatty Liver Disease/complications; Non-alcoholic Fatty Liver Disease/immunology

Key words

autophagy; fibrosis; glucose metabolism; hepatic stellate cells; hepatocytes; immunometabolism; innate-like lymphoid cells; lipid metabolism; macrophages; nuclear receptors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes / Signal Transduction / Hepatocytes / Hepatic Stellate Cells / Non-alcoholic Fatty Liver Disease / Antifibrotic Agents / Liver Cirrhosis / Macrophages Limits: Animals / Humans Language: En Journal: J Hepatol Journal subject: GASTROENTEROLOGIA Year: 2021 Document type: Article Affiliation country: France Country of publication: Netherlands

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