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A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition.
Kitajima, Shojiro; Sun, Wendi; Lee, Kian Leong; Ho, Jolene Caifeng; Oyadomari, Seiichi; Okamoto, Takashi; Masai, Hisao; Poellinger, Lorenz; Kato, Hiroyuki.
Affiliation
  • Kitajima S; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore, 117599, Republic of Singapore.
  • Sun W; Institute for Advanced Biosciences, Keio University, Kakuganji 246-2, Mizukami, Tsuruoka, Yamagata, 997-0052, Japan.
  • Lee KL; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore, 117599, Republic of Singapore.
  • Ho JC; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore, 117599, Republic of Singapore.
  • Oyadomari S; Cancer & Stem Cell Biology Programme, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Republic of Singapore.
  • Okamoto T; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, Singapore, 117599, Republic of Singapore.
  • Masai H; Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 770-8503, Japan.
  • Poellinger L; Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Science, Mizuho-ku, Nagoya, 467-8601, Japan.
  • Kato H; Genome Dynamics Project, Department of Basic Medical Sciences, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.
Sci Rep ; 11(1): 4538, 2021 02 25.
Article in En | MEDLINE | ID: mdl-33633164
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / EIF-2 Kinase / Enzyme Inhibitors / Activating Transcription Factor 4 / Histone Demethylases Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / EIF-2 Kinase / Enzyme Inhibitors / Activating Transcription Factor 4 / Histone Demethylases Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Country of publication: United kingdom