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Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein.
Fukai, Ryota; Ogo, Naohisa; Ichida, Taiki; Yamane, Masayoshi; Sawada, Jun-Ichi; Miyoshi, Nao; Murakami, Hisashi; Asai, Akira.
Affiliation
  • Fukai R; Center for Drug Discovery, Graduate Division of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka, 422-8526, Japan.
  • Ogo N; Center for Drug Discovery, Graduate Division of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka, 422-8526, Japan. Electronic address: ogo@u-shizuoka-ken.ac.jp.
  • Ichida T; Center for Drug Discovery, Graduate Division of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka, 422-8526, Japan.
  • Yamane M; Center for Drug Discovery, Graduate Division of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka, 422-8526, Japan.
  • Sawada JI; Center for Drug Discovery, Graduate Division of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka, 422-8526, Japan.
  • Miyoshi N; Center for Drug Discovery, Graduate Division of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka, 422-8526, Japan.
  • Murakami H; Center for Drug Discovery, Graduate Division of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka, 422-8526, Japan.
  • Asai A; Center for Drug Discovery, Graduate Division of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka, 422-8526, Japan. Electronic address: aasai@u-shizuoka-ken.ac.jp.
Eur J Med Chem ; 215: 113288, 2021 Apr 05.
Article in En | MEDLINE | ID: mdl-33640763
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trityl Compounds / Prodrugs / Kinesins / Cysteine / Dibenzocycloheptenes / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Affiliation country: Japan Country of publication: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trityl Compounds / Prodrugs / Kinesins / Cysteine / Dibenzocycloheptenes / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Affiliation country: Japan Country of publication: France