Diversification of the vertebrate limb: sequencing the events.
Curr Opin Genet Dev
; 69: 42-47, 2021 08.
Article
in En
| MEDLINE
| ID: mdl-33647833
ABSTRACT
Naturalists leading up to the early 20th century were captivated by the diversity of limb form and function and described its development in a variety of species. The advent of discoveries in genetics followed by molecular biology led to focused efforts in few 'model' species, namely mouse and chicken, to understand conserved mechanisms of limb axis specification and development of the musculoskeletal system. 'Non-traditional' species largely fell by the wayside until their recent resurgence into the spotlight with advances in next-generation sequencing technologies (NGS). In this review, we focus on how the use of NGS has provided insights into the development, loss, and diversification of amniote limbs. Coupled with advances in chromatin interrogation techniques and functional tests in vivo, NGS is opening possibilities to understand the genetic mechanisms that govern the remarkable radiation of vertebrate limb form and function.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Variation
/
Musculoskeletal Development
/
Extremities
Limits:
Animals
Language:
En
Journal:
Curr Opin Genet Dev
Journal subject:
GENETICA
Year:
2021
Document type:
Article
Affiliation country:
United States