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Variations in IL-22, IL-27 and IL-35 serum levels in untreated and treated hepatitis C patients.
Taghinejad, Azam; Barani, Shaghik; Gholijani, Naser; Ghandehari, Farzad; Khansalar, Soolmaz; Asadipour, Morvarid; Davarpanah, Mohammadali; Fattahi, Mohammadreza; Kalantar, Kurosh.
Affiliation
  • Taghinejad A; Gastroenterology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Barani S; Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Gholijani N; Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Ghandehari F; Gastroenterology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Khansalar S; Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Asadipour M; Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Davarpanah M; Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Fattahi M; Gastroenterology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Kalantar K; Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
Eur Cytokine Netw ; 31(4): 134-139, 2020 Dec 01.
Article in En | MEDLINE | ID: mdl-33648921
BACKGROUND: Hepatitis C virus (HCV) is the leading cause of chronic liver diseases including hepatic fibrosis, cirrhosis, and hepatocellular carcinoma. We aimed to assess serum levels of interleukin (IL)-22, IL-27 and IL-35 in patients with hepatitis C and healthy controls to investigate their possible relationship with viral genotypes and liver enzyme levels. METHOD: A total of 30 newly diagnosed hepatitis C patients with no history of antiviral therapy and 30 healthy individuals participated in this study. Serum levels of IL-22, IL-27 and IL-35 were determined by ELISA in peripheral blood samples from patients prior to and following treament with pan-genotypic direct-acting anti-viral therapy. Serum levels of alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) were measured to determine any possible association between hepatic enzymes and cytokine serum levels concentrations. RESULT: The results show elevated serum levels of of IL-35 in HCV-infected patients compared to treated cases and healthy controls, whereas there was no significant difference in IL-22 and IL-27 serum levels among the three groups. Additionally, the cytokine levels were not significantly correlated with certain genotypes and levels of liver enzymes. CONCLUSION: Our findings indicate a potential role for IL-35 in chronic HCV infection and therapeutic management of patients with hepatitis C infection.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Cytokines / Hepatitis C / Hepacivirus Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Eur Cytokine Netw Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Document type: Article Affiliation country: Iran Country of publication: France

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Cytokines / Hepatitis C / Hepacivirus Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Eur Cytokine Netw Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Document type: Article Affiliation country: Iran Country of publication: France