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Thrombocytopathies: Not Just Aggregation Defects-The Clinical Relevance of Procoagulant Platelets.
Aliotta, Alessandro; Bertaggia Calderara, Debora; Zermatten, Maxime G; Marchetti, Matteo; Alberio, Lorenzo.
Affiliation
  • Aliotta A; Hemostasis and Platelet Research Laboratory, Division of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), CH-1010 Lausanne, Switzerland.
  • Bertaggia Calderara D; Hemostasis and Platelet Research Laboratory, Division of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), CH-1010 Lausanne, Switzerland.
  • Zermatten MG; Hemostasis and Platelet Research Laboratory, Division of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), CH-1010 Lausanne, Switzerland.
  • Marchetti M; Hemostasis and Platelet Research Laboratory, Division of Hematology and Central Hematology Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), CH-1010 Lausanne, Switzerland.
  • Alberio L; Service de Médecine Interne, Hôpital de Nyon, CH-1260 Nyon, Switzerland.
J Clin Med ; 10(5)2021 Feb 24.
Article in En | MEDLINE | ID: mdl-33668091
ABSTRACT
Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in thrombocytopathies variously characterized by defects of their adhesive and procoagulant activation endpoints. In this review, we summarize the traditional platelet defects in adhesion, secretion, and aggregation. In addition, we review the current knowledge about procoagulant platelets, focusing on their role in bleeding or thrombotic pathologies and their pharmaceutical modulation. Procoagulant activity is an important feature of platelet activation, which should be specifically evaluated during the investigation of a suspected thrombocytopathy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Qualitative_research Language: En Journal: J Clin Med Year: 2021 Document type: Article Affiliation country: Switzerland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Qualitative_research Language: En Journal: J Clin Med Year: 2021 Document type: Article Affiliation country: Switzerland