Human Papillomavirus and Cellular Pathways: Hits and Targets.
Pathogens
; 10(3)2021 Feb 25.
Article
in En
| MEDLINE
| ID: mdl-33668730
ABSTRACT
The Human Papillomavirus (HPV) is the causative agent of different kinds of tumors, including cervical cancers, non-melanoma skin cancers, anogenital cancers, and head and neck cancers. Despite the vaccination campaigns implemented over the last decades, we are far from eradicating HPV-driven malignancies. Moreover, the lack of targeted therapies to tackle HPV-related tumors exacerbates this problem. Biomarkers for early detection of the pathology and more tailored therapeutic approaches are needed, and a complete understanding of HPV-driven tumorigenesis is essential to reach this goal. In this review, we overview the molecular pathways implicated in HPV infection and carcinogenesis, emphasizing the potential targets for new therapeutic strategies as well as new biomarkers.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Screening_studies
Language:
En
Journal:
Pathogens
Year:
2021
Document type:
Article
Affiliation country:
Italy