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Retinal Neurodegeneration: Correlation between Nutraceutical Treatment and Animal Model.
Piano, Ilaria; Di Paolo, Mattia; Corsi, Francesca; Piragine, Eugenia; Bisti, Silvia; Gargini, Claudia; Di Marco, Stefano.
Affiliation
  • Piano I; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56121 Pisa, Italy.
  • Di Paolo M; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56121 Pisa, Italy.
  • Corsi F; Interuniversity Consortium -Biostructures and Biosystems National Institute (INBB), Via Medaglie d'Oro 305, 00136 Roma, Italy.
  • Piragine E; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56121 Pisa, Italy.
  • Bisti S; Institute of Neuroscience-CNR, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.
  • Gargini C; Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56121 Pisa, Italy.
  • Di Marco S; Interuniversity Consortium -Biostructures and Biosystems National Institute (INBB), Via Medaglie d'Oro 305, 00136 Roma, Italy.
Nutrients ; 13(3)2021 Feb 27.
Article in En | MEDLINE | ID: mdl-33673449
Retinal diseases can be induced by a variety of factors, including gene mutations, environmental stresses and dysmetabolic processes. The result is a progressive deterioration of visual function, which sometimes leads to blindness. Many treatments are under investigation, though results are still mostly unsatisfactory and restricted to specific pathologies, particularly in the case of gene therapy. The majority of treatments have been tested in animal models, but very few have progressed to human clinical trials. A relevant approach is to study the relation between the type of treatments and the degenerative characteristics of the animal model to better understand the effectiveness of each therapy. Here we compare the results obtained from different animal models treated with natural compounds (saffron and naringenin) to anticipate the potentiality of a single treatment in different pathologies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Diseases / Plant Extracts / Neurodegenerative Diseases / Crocus / Flavanones / Retinal Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nutrients Year: 2021 Document type: Article Affiliation country: Italy Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Diseases / Plant Extracts / Neurodegenerative Diseases / Crocus / Flavanones / Retinal Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nutrients Year: 2021 Document type: Article Affiliation country: Italy Country of publication: Switzerland