Muscle Stem Cell Quiescence: Controlling Stemness by Staying Asleep.
Trends Cell Biol
; 31(7): 556-568, 2021 07.
Article
in En
| MEDLINE
| ID: mdl-33674167
ABSTRACT
Muscle stem cells (MuSCs) are tissue-resident stem cells required for growth and repair of skeletal muscle, that are otherwise maintained in a cell-cycle-arrested state called quiescence. While quiescence was originally believed to be a state of cellular inactivity, increasing evidence suggests that quiescence is dynamically regulated and contributes to stemness, the long-term capacity to maintain regenerative functions. Here, we review the current understanding of MuSC quiescence and highlight recently discovered molecular markers, which differentiate depth of quiescence and influence self-renewal capacity. We also discuss how quiescent MuSCs integrate paracrine factors from their niche and dynamically regulate cell signaling, metabolism and proteostasis as they anticipate physiological needs, and how perturbing these cues during aging impairs muscle regeneration.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stem Cells
/
Myoblasts
Language:
En
Journal:
Trends Cell Biol
Year:
2021
Document type:
Article
Affiliation country:
Switzerland