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Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice.
Liu, Pengfei; Gao, Quansheng; Guan, Lei; Hu, Yanting; Jiang, Jingwen; Gao, Teng; Sheng, Weixuan; Xue, Xinying; Qiao, Hui; Li, Tianzuo.
Affiliation
  • Liu P; Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Gao Q; Department of Operational Medicine, Tianjin Institute of Environmental & Operational Medicine, Tianjin 300050, China.
  • Guan L; Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Hu Y; Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Jiang J; Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Gao T; Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Sheng W; Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Xue X; Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Qiao H; Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
  • Li T; Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Acta Biochim Biophys Sin (Shanghai) ; 53(5): 528-537, 2021 Apr 15.
Article in En | MEDLINE | ID: mdl-33674828
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Surgical Procedures, Operative / Aging / Blood-Brain Barrier / Signal Transduction / NF-kappa B / Inflammasomes / Cognitive Dysfunction / Atorvastatin / NLR Family, Pyrin Domain-Containing 3 Protein Type of study: Etiology_studies Limits: Animals Language: En Journal: Acta Biochim Biophys Sin (Shanghai) Journal subject: BIOFISICA / BIOQUIMICA Year: 2021 Document type: Article Affiliation country: China Country of publication: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Surgical Procedures, Operative / Aging / Blood-Brain Barrier / Signal Transduction / NF-kappa B / Inflammasomes / Cognitive Dysfunction / Atorvastatin / NLR Family, Pyrin Domain-Containing 3 Protein Type of study: Etiology_studies Limits: Animals Language: En Journal: Acta Biochim Biophys Sin (Shanghai) Journal subject: BIOFISICA / BIOQUIMICA Year: 2021 Document type: Article Affiliation country: China Country of publication: China