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Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav 1.5 by the Antiarrhythmic Drug Quinidine*.
Li, Zhangqiang; Jin, Xueqin; Wu, Tong; Huang, Gaoxingyu; Wu, Kun; Lei, Jianlin; Pan, Xiaojing; Yan, Nieng.
Affiliation
  • Li Z; State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Science, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
  • Jin X; State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Science, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
  • Wu T; State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Science, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
  • Huang G; Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, 310024, Zhejiang Province, China.
  • Wu K; Medical Research Center, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
  • Lei J; Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
  • Pan X; State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Science, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
  • Yan N; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Angew Chem Int Ed Engl ; 60(20): 11474-11480, 2021 05 10.
Article in En | MEDLINE | ID: mdl-33684260
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinidine / NAV1.5 Voltage-Gated Sodium Channel / Anti-Arrhythmia Agents Limits: Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2021 Document type: Article Affiliation country: China Country of publication: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinidine / NAV1.5 Voltage-Gated Sodium Channel / Anti-Arrhythmia Agents Limits: Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2021 Document type: Article Affiliation country: China Country of publication: Germany