Water-soluble poly(ethylene glycol) methyl ether-grafted chitosan/alginate polyelectrolyte complex hydrogels.
Int J Biol Macromol
; 179: 353-365, 2021 May 15.
Article
in En
| MEDLINE
| ID: mdl-33684431
ABSTRACT
This study aimed to fabricate polyelectrolyte complexes from water-soluble poly(ethylene glycol) methyl ether-grafted chitosan (mPEG-g-CTS) and alginate (ALG) in the absence of acetic acid. The complexes formed fibrous network macrogels when mPEG-g-CTS with short mPEG chains (mPEG750-g-CTS and mPEG2000-g-CTS) and mPEG-g-CTSALG weight ratios in the range from 10.14 to 11 were used. The macrogels at a weight ratio of mPEG-g-CTSALG of 11 possessed the highest elasticity with electrophoretic mobility close to 0 m2·V-1·s-1. Water uptake of the sponge-like lyophilized macrogels decreased with increasing ALG content, mPEG chain length, and degree of substitution of mPEG-g-CTS. In contrast, the polyelectrolyte complexes prepared using long mPEG chains of mPEG-g-CTS (mPEG5000-g-CTS) formed spherical nanoparticles (70-90 nm) and showed highly negative electrophoretic mobility (< -3.20 × 108 m2·V-1·s-1). The obtained mPEG-g-CTS/ALG polyelectrolyte complex hydrogels and nanoparticles have the potential to be applied as carriers for functional food additives, drugs, and bioactive compounds.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biocompatible Materials
/
Hydrogels
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Chitosan
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Alginates
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Nanoparticles
Language:
En
Journal:
Int J Biol Macromol
Year:
2021
Document type:
Article
Affiliation country:
Thailand