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HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.
Fazal, Raheem; Boeynaems, Steven; Swijsen, Ann; De Decker, Mathias; Fumagalli, Laura; Moisse, Matthieu; Vanneste, Joni; Guo, Wenting; Boon, Ruben; Vercruysse, Thomas; Eggermont, Kristel; Swinnen, Bart; Beckers, Jimmy; Pakravan, Donya; Vandoorne, Tijs; Vanden Berghe, Pieter; Verfaillie, Catherine; Van Den Bosch, Ludo; Van Damme, Philip.
Affiliation
  • Fazal R; Department of Neurosciences, Experimental Neurology, Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
  • Boeynaems S; Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, Leuven, Belgium.
  • Swijsen A; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
  • De Decker M; Department of Neurosciences, Experimental Neurology, Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
  • Fumagalli L; Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, Leuven, Belgium.
  • Moisse M; Department of Neurosciences, Experimental Neurology, Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
  • Vanneste J; Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, Leuven, Belgium.
  • Guo W; Department of Neurosciences, Experimental Neurology, Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
  • Boon R; Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, Leuven, Belgium.
  • Vercruysse T; Department of Neurosciences, Experimental Neurology, Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
  • Eggermont K; Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, Leuven, Belgium.
  • Swinnen B; Department of Neurosciences, Experimental Neurology, Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
  • Beckers J; Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, Leuven, Belgium.
  • Pakravan D; Department of Neurosciences, Experimental Neurology, Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
  • Vandoorne T; Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, Leuven, Belgium.
  • Vanden Berghe P; Stem Cell Institute, Department of Development and Regeneration, Stem Cell Biology and Embryology, KU Leuven, Leuven, Belgium.
  • Verfaillie C; Stem Cell Institute, Department of Development and Regeneration, Stem Cell Biology and Embryology, KU Leuven, Leuven, Belgium.
  • Van Den Bosch L; Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
  • Van Damme P; Department of Neurosciences, Experimental Neurology, Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.
EMBO J ; 40(7): e106177, 2021 04 01.
Article in En | MEDLINE | ID: mdl-33694180
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Axonal Transport / DNA-Binding Proteins / Histone Deacetylase 6 / Amyotrophic Lateral Sclerosis / Motor Neurons Limits: Humans Language: En Journal: EMBO J Year: 2021 Document type: Article Affiliation country: Belgium
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Axonal Transport / DNA-Binding Proteins / Histone Deacetylase 6 / Amyotrophic Lateral Sclerosis / Motor Neurons Limits: Humans Language: En Journal: EMBO J Year: 2021 Document type: Article Affiliation country: Belgium