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Transcriptional profiling reveals the transcription factor networks regulating the survival of striatal neurons.
Yang, Lin; Su, Zihao; Wang, Ziwu; Li, Zhenmeiyu; Shang, Zicong; Du, Heng; Liu, Guoping; Qi, Dashi; Yang, Zhengang; Xu, Zhejun; Zhang, Zhuangzhi.
Affiliation
  • Yang L; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Shanghai Key Lab of Birth Defect, Children's Hospital, Fudan University, Shanghai, 200032, P.R. China.
  • Su Z; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Shanghai Key Lab of Birth Defect, Children's Hospital, Fudan University, Shanghai, 200032, P.R. China.
  • Wang Z; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Shanghai Key Lab of Birth Defect, Children's Hospital, Fudan University, Shanghai, 200032, P.R. China.
  • Li Z; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Shanghai Key Lab of Birth Defect, Children's Hospital, Fudan University, Shanghai, 200032, P.R. China.
  • Shang Z; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Shanghai Key Lab of Birth Defect, Children's Hospital, Fudan University, Shanghai, 200032, P.R. China.
  • Du H; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Shanghai Key Lab of Birth Defect, Children's Hospital, Fudan University, Shanghai, 200032, P.R. China.
  • Liu G; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Shanghai Key Lab of Birth Defect, Children's Hospital, Fudan University, Shanghai, 200032, P.R. China.
  • Qi D; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Shanghai Key Lab of Birth Defect, Children's Hospital, Fudan University, Shanghai, 200032, P.R. China.
  • Yang Z; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Shanghai Key Lab of Birth Defect, Children's Hospital, Fudan University, Shanghai, 200032, P.R. China.
  • Xu Z; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Shanghai Key Lab of Birth Defect, Children's Hospital, Fudan University, Shanghai, 200032, P.R. China. 14111520028@fudan.edu.cn.
  • Zhang Z; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, MOE Frontier Research Center for Brain Science, Shanghai Key Lab of Birth Defect, Children's Hospital, Fudan University, Shanghai, 200032, P.R. China. zz_zhang@fudan.edu.cn.
Cell Death Dis ; 12(3): 262, 2021 03 12.
Article in En | MEDLINE | ID: mdl-33712552
ABSTRACT
The striatum is structurally highly diverse, and its organ functionality critically depends on normal embryonic development. Although several studies have been conducted on the gene functional changes that occur during striatal development, a system-wide analysis of the underlying molecular changes is lacking. Here, we present a comprehensive transcriptome profile that allows us to explore the trajectory of striatal development and identify the correlation between the striatal development and Huntington's disease (HD). Furthermore, we applied an integrative transcriptomic profiling approach based on machine learning to systematically map a global landscape of 277 transcription factor (TF) networks. Most of these TF networks are linked to biological processes, and some unannotated genes provide information about the corresponding mechanisms. For example, we found that the Meis2 and Six3 were crucial for the survival of striatal neurons, which were verified using conditional knockout (CKO) mice. Finally, we used RNA-Seq to speculate their downstream targets.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Apoptosis / Huntington Disease / Corpus Striatum / Gene Expression Profiling / Gene Regulatory Networks / Transcriptome Type of study: Observational_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Death Dis Year: 2021 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Apoptosis / Huntington Disease / Corpus Striatum / Gene Expression Profiling / Gene Regulatory Networks / Transcriptome Type of study: Observational_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Death Dis Year: 2021 Document type: Article