Ir-Catalyzed Selective B(3)-H Amination of o-Carboranes with NH3.
J Am Chem Soc
; 143(11): 4148-4153, 2021 Mar 24.
Article
in En
| MEDLINE
| ID: mdl-33719434
ABSTRACT
Ammonia gas, NH3, is a cheap and widely used industrial feedstock, which has received tremendous research interests in its functionalization. This work reports a breakthrough in catalytic selective cage B(3)-H amination of o-carboranes with NH3 via Ir-catalyzed B-H/N-H dehydrocoupling, offering convenient and efficient access to a series of 3-NH2-o-carborane derivatives in moderate to high isolated yields with a broad substrate scope. The employment of readily available NH3 gas as the aminating reagent with H2 as the sole byproduct endows the protocol economy, practicability, and environmental friendliness. A plausible reaction mechanism is proposed on the basis of control experiments.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Guideline
Language:
En
Journal:
J Am Chem Soc
Year:
2021
Document type:
Article
Affiliation country:
China